2,4-Dinitrophenol

• "Pure Caffeine 200mg"

DNP is one of the most controversial drugs in use by bodybuilders. This agent is not sold for human use anywhere in the world at this time, but is readily available as an industrial chemical. Among other things, it is used as an intermediary for the production of certain dyes, for photographic development, as a fungicide, in wood pressure-treatment to prevent rotting, and as an insecticide. It is technically classified as a poison. Although quite incongruous with this list of strong industrial/chemical uses, this chemical was sold during the era of patent medicine as a diet drug for humans. It is this property of dinitrophenol that remains of interest to some bodybuilders today. Dinitrophenol induces weight loss by uncoupling oxidative phosphorylation, thereby markedly increasing the metabolic rate and body temperature . While this is an extremely effective way of producing rapid weight loss, there seems to be no ceiling to DNP's temperature increasing effect. Herein lies perhaps its most dangerous trait; it may allow body temperature to rise to level that can be damaging, even fatal. Writer Carl Malmberg made perhaps one of the earliest and most famous quotes about this danger back in the 1930s when he told of a physician who was "literally cooked to death" from using it. This was far from an isolated case, and deaths associated with DNP have continued over the decades. (©William Llewellyn, Taken from “Anabolics 2009”) Therapeutic use: There are no therapeutic uses for DNP. How it is supplied: DNP is not supplied in a form prepared for human or veterinary consumption. It is available as a research or industrial chemical only. (©William Llewellyn, Taken from “Anabolics 2009”) How it is used: DNP is not approved for use in humans. Prescribing guidelines are unavailable. A common dose used among bodybuilders is reportedly 2mg per kg of bodyweight per day. This calculates to a dosage of 200 mg per day for a person of approximately 220 pounds of bodyweight. Note that this population tends to retain more lean muscle mass than the average (sedentary) person of the same bodyweight, which may substantially alter the results and side effects of a given dosage. Admittedly, fat loss due to DNP use is highly rapid and extreme/ with some people losing as much as .5 to 1 pound of fat weight per day. This can equate to a drop of 15 or 20 pounds in only a few weeks. Given the high risks associated with DNP use, however, it is usually taken for only a few weeks at a time. The strong incidence of side effects is also regarded as an indicator that the drug should be discontinued immediately. Note that most experts regard DNP as a drug with inherent dangers that far outweigh its potential benefits. (©William Llewellyn, Taken from “Anabolics 2009”)

There are many potential side effects associated with DNP use including increased heart rate, increased breathing rate, nausea, elevated body temperature, insomnia, profuse sweating, rash, skin lesions, decreased white blood cell count, cataracts, coma, and death. (©William Llewellyn, Taken from “Anabolics 2009”)