Long term effects can include restlessness, acute anxiety, Dependence, Withdrawal symptoms if stopped abruptly, irritability, headaches, anxiety. Aggravation of the digestive system and heart problems. In large amounts, and especially over extended periods of time, caffeine can lead to a condition known as caffeinism. Caffeinism usually combines caffeine dependency with a range of physical and mental symptoms including nervousness, irritability, anxiety, muscle twitches, Insomnia, headaches, heart palpitations, and high usage over time can lead to peptic ulcers and other gastrointestinal problems as caffeine increases the production of stomach acid. There are four caffeine-induced psychiatric disorders: caffeine intoxication, caffeine-induced anxiety disorder, caffeine-induced sleep disorder, and caffeine-related disorder not otherwise specified (NOS).