General features: Nausea, vomiting, diarrhoea, abdominal pain, flushing, rash, tinnitus and impaired hearing.
Cardiac features: Tachycardia, dysrhythmias, hypotension, QT and/or QRS prolongation, torsade de pointes and cardiac arrest may occur.
Visual features: Blurred vision, defective colour perception, visual field constriction and blindness may occur. These effects may be delayed for up to 12-18 hours. Visual loss is predominantly in the peripheral fields in milder cases.
Other features: Oliguria and acute kidney injury from intravascular haemolysis, thrombocytopenia, hypokalaemia, convulsions and coma (especially in children) have been reported.
Hypoglycaemia, from quinine-induced insulin release, has also been reported in both therapeutic use and acute overdose.
