For treatment of erectile dysfunction and pulmonary arterial hypertension, increasing the effects of nitric oxide by inhibiting the breakdown of cyclic GMP.
Short term effects
Headache, flushing, nausea, vomiting and nasal congestion have all been reported.
Visual disturbance including abnormalities of colour vision and even blindness may occur due to optic neuropathy or retinal artery occlusion.
Cardiovascular features include palpitations, tachycardia and hyper- or hypotension.